吖啶黄
吖啶黄 性质
| 熔点 | 179-181 °C |
|---|---|
| 沸点 | 612.69°C (rough estimate) |
| 密度 | 1.0933 (rough estimate) |
| 折射率 | 1.6000 (estimate) |
| 储存条件 | Store at -20°C |
| 溶解度 | 在水中的溶解度为0.33g/mL(lit.)(lit.) |
| 形态 | 粉末 |
| 颜色 | 深橙色至棕红色 |
| Merck | 14,123 |
| CAS 数据库 | 8048-52-0(CAS DataBase Reference) |
| EPA化学物质信息 | Xanthacridinum (8048-52-0) |
吖啶黄 用途与合成方法
Acriflavine is identified as a potent inhibitor of the MCT4 that can inhibit the binding between Basigin and MCT4. Acriflavine significantly inhibits growth and self-renewal potential of several glioblastoma neurosphere lines. The HIF-1 inhibitor acriflavine decreases survival and growth of CML cells. It targets stem cell potential of CML cells.
Acriflavine treatment inhibits intratumoral expression of VEGF and tumor vascularization. In a murine CML model, acriflavine decreases leukemia development and reduces LSC maintenance. Acriflavine retards tumor growth in a murine model of breast cancer. The combination of sunitinib with acriflavine significantly decreases vascular endothelial growth factor and TGF-β expression and reduces tumor vasculature followed by increased intratumor necrosis and apoptosis.
安全信息
| 危险品标志 | Xn,N |
|---|---|
| 危险类别码 | 22-37/38-41-50/53-20/21/22-50-36/37/38 |
| 安全说明 | 26-39-60-61-36-37/39-29-36/37/39 |
| 危险品运输编号 | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| RTECS号 | AR9660000 |
| 海关编码 | 38249064 |
吖啶黄 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-11 | XW80485202 | 吖啶黄素 | 8048-52-0 | 25G | 483 |
| 2024-11-11 | XW80485201 | 吖啶黄素 | 8048-52-0 | 5G | 114 |
