3-Pyridinol, 2-amino-5-nitro-

21594-54-7

908248-27-1

The general procedure for the synthesis of 2-amino-5-nitropyridin-3-ol using 6-nitrooxazolo[4,5-b]pyridin-2(3H)-one as starting material was as follows: to a solution of 6-nitrooxazolo[4,5-b]pyridin-2(3H)-one (124 mmol) in ethanol (100 mL), a solution of sodium hydroxide (500 mmol) in water (180 mL) was added. The reaction mixture was heated to reflux at 80°C for 3 hours. Upon completion of the reaction, the reaction was quenched with concentrated hydrochloric acid (40 mL), followed by adjusting the pH with 2 M sodium carbonate solution to 8. The precipitated solid was collected by filtration to afford the target product, 2-amino-5-nitropyridin-3-ol, in 86% yield and the product was a yellow solid.