METHYL CAFFEATE

Caffeic acid methyl ester is an ester of a naturally occurring phenolic compound found in P. amplexicaule var. sinense and S. torvum fruits. At 40 mg/kg, it demonstrates antihyperglycemic and antidiabetic activity in diabetic rats, upregulating GLUT4 and regenerating pancreatic β-cells. At 10 mg/kg, it can induce anti-inflammatory and antinociceptive effects in rat models of edema and pain, inhibiting nitric oxide and prostaglandin E₂ production, as well as tumor necrosis factor-α release.

slightly yellowish solid

Inhibitor of protein tyrosine kinase

ChEBI: An alkyl caffeate ester formed by the formal condensation of caffeic acid with methyl alcohol.

[1] GOPALSAMY RAJIV GANDHI . Antihyperglycemic activity and antidiabetic effect of methyl caffeate isolated from Solanum torvum Swartz. fruit in streptozotocin induced diabetic rats[J]. European journal of pharmacology, 2011, 670 2: Pages 623-631. DOI: 10.1016/j.ejphar.2011.09.159
[2] KYUNG-MIN SHIN . Anti-inflammatory effect of caffeic acid methyl ester and its mode of action through the inhibition of prostaglandin E2, nitric oxide and tumor necrosis factor-α production[J]. Biochemical pharmacology, 2004, 68 12: Pages 2327-2336. DOI: 10.1016/j.bcp.2004.08.002