6-Chloro-imidazo[1,2-b]pyridazine-3-methanol

50-00-0

6775-78-6

675580-49-1

General procedure for the synthesis of 6-chloroimidazo[1,2-b]pyridazine-3-methanol from formaldehyde and 6-chloroimidazo[1,2-b]pyridazine: 1. Preparation of the intermediate 6-chloroimidazo[1,2-b]pyridazine-3-carbaldehyde: To a solution of 6-chloroimidazo[1,2-b]pyridazine (1.5 g, 9.8 mmol) in chloroform (150 mL) was added sodium acetate (1.4 g, 17.1 mmol) and paraformaldehyde (1.5 g). The reaction mixture was heated to reflux overnight. 2. Post-treatment: After completion of the reaction, the mixture was concentrated under reduced pressure. The residue was adjusted to pH=12 with base, filtered and the solid was washed with ethanol to afford 6-chloroimidazo[1,2-b]pyridazine-3-methanol (1.3 g, 72% yield).