flavipucine

Flavipucine (Flavipucin), a glutarimide antibiotic, is found in the strain of Aspergillus flavipes F-2090/7. Flavipucine has antibacterial activity against B. subtilis. Flavipucine has antiprotozoal activity. Flavipucine has cytotoxic activity against several cancer cells[1][2].

[1] Kusakabe Y, et al. Synthesis, antibacterial and cytotoxic evaluation of flavipucine and its derivatives. Bioorg Med Chem Lett. 2019 Jun 1;29(11):1390-1394. DOI:10.1016/j.bmcl.2019.03.034
[2] Boya P CA, et al. Antiprotozoal Natural Products from Endophytic Fungi Associated with Cacao and Coffee. Metabolites. 2024 Oct 25;14(11):575. DOI:10.3390/metabo14110575