4,5-Dehydro DHA

Docosahexaenoic acid (DHA; 22:6ω3) is one of the essential dietary ω-3 unsaturated fatty acids and the preferred n-3 fatty acid for development of the brain and retina.¹ 4,5-dehydro DHA is a novel analog of DHA in which the double bond closest to the carboxyl group has been converted into an acetylene. 4,5-dehydro DHA is a novel compound that has not been studied in biological systems. However, the corresponding acetylene in the C-20 fatty acid series (5,6-dehydro arachidonic acid) is a well known inhibitor of 5-lipoxygenase.²

(7Z,10Z,13Z,16Z,19Z)-Docosa-7,10,13,16,19-pentaen-4-ynoic acid is an ester product.

ChEBI: 4,5-dehydro Docosahexaenoic Acid is a very long-chain fatty acid.

1. Anderson, G.J., Connor, W.E., and Corliss, J.D. Docosahexaenoic acid is the preferred dietary n-3 fatty acid for the development of the brain and retina Pediatr. Res. 27,89-97(1990).
2. Sok, D.E., Han, C.Q., Pai, J.K., et al. Inhibition of leukotriene biosynthesis by acetylenic analogs Biochem. Biophys. Res. Commun. 107,101-108(1982).