hamaudol

Product Namehamaudol
CAS735-46-6
MFC15H16O5
MW276.28
EINECS
MOL File735-46-6.mol

Chemical Properties

Melting point	197.0-197.5 °C
Boiling point	464.7±45.0 °C(Predicted)
Density	1.336±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Solid
pka	6.77±0.70(Predicted)
color	White to off-white

Usage And Synthesis

Uses

Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX)-1 and COX-2 activities with IC50 values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects[1][2].

Definition

ChEBI: Hamaudol is a member of chromenes.

Biological Activity

Hamaudol is a chromone isolated from Saposhnikovia divaricata. It has obvious inhibitory ability on the activities of cyclooxygenase (COX)-1 and COX-2 with IC50 values of 0.30 and 0.57 mM, respectively, and has potent analgesic and anti-inflammatory effects.

in vivo

Hamaudol (Compound 7) increases the potency to exhibit a potent analgesia at doses of 1, 5 and 10 mg/kg in mice, although it do not show clear dose dependency.

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target

COX-1

< span> 0.3 mM (IC ₅₀ )

COX-2

0.57 mM (IC ₅₀ )

IC 50

COX-1: 0.3 mM (IC₅₀); COX-2: 0.57 mM (IC₅₀)

References

[1] Okuyama E, et al. Analgesic components of saposhnikovia root (Saposhnikovia divaricata). Chem Pharm Bull (Tokyo). 2001 Feb;49(2):154-60. DOI:10.1248/cpb.49.154
[2] Mingshan Zheng, et al. The Constituents Isolated from Peucedanum japonicum Thunb. and their Cyclooxygenase (COX) Inhibitory Activity. Korean Journal of Medicinal Crop Science, 2005, 13(2).