bruceine E

Product Namebruceine E
CAS21586-90-3
MFC20H28O9
MW412.43
EINECS
MOL File21586-90-3.mol

Chemical Properties

Melting point	262-263 °C
Boiling point	632.635±55.00 °C(Press: 760.00 Torr)(predicted)
Density	1.609±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka	11.502±0.70(predicted)
form	Solid
color	White to off-white

Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from the fruit of Brucea javanica.

Uses

Bruceine E is a quassinoid from seeds of Brucea javanica (L.) Merr, exhibiting hypoglycemia effect[1]. Bruceine E exhibits blood glucose lowering effect in both nondiabetic mice and Streptozotocin (STZ (HY-13753))-induced diabetic rats at lower dose[2].

in vivo

Bruceine D and E, isolated from B. javanica seeds, exhibits blood glucose lowering effect in both nondiabetic mice and STZ-induced diabetic rats at lower dose (1 mg/kg b.w.) during 0-8 h screening^[2].

References

[1] Man F, et al. HPLC-MS/MS method for bioavailability study of bruceines D & E in rat plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 15;1063:183-188. DOI:10.1016/j.jchromb.2017.08.037
[2] Ablat A, et al. Antidiabetic effects of Brucea javanica seeds in type 2 diabetic rats. BMC Complement Altern Med. 2017;17(1):94. Published 2017 Feb 6. DOI:10.1186/s12906-017-1610-x