saikogenin A

Product Namesaikogenin A
CAS5092-09-1
MFC30H48O4
MW472.7
EINECS
MOL File5092-09-1.mol

Chemical Properties

Melting point	287-293 °C
Boiling point	607.4±55.0 °C(Predicted)
Density	1.16±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Solid
pka	14.47±0.70(Predicted)
color	White to off-white

Usage And Synthesis

Biological Activity

Saikogenin A, extracted from the traditional Chinese medicine Bupleurum, is a dipeptidyl peptidase IV (DPP-IV) inhibitor.

Biochem/physiol Actions

Saikogenin A is a naturally occurring plant extract that has been shown to have a variety of biological activities. saikogenin A has anti-inflammatory and tumour cell growth inhibiting effects. Its anti-inflammatory effect is due to an increase in corticosterone caused by the release of ACTH and has a direct effect on the inflammatory process. It also inhibits the absorption of ultraviolet light by human skin cells and erythromycin-induced UvB damage.

in vitro

Saikogenin A has certain inhibitory effect on the enzyme DPP-IV. At a concentration of 20 μg/mL DPP-IV inhibition is 47.6%. DPP-IV is a non-classical serine aminopeptidase from its amino terminus of polypeptides and proteins (N-terminus) removing Xaa-Pro dipeptide.

in vivo

Saikogenin A, an anti-inflammatory drug, is present in the crude extract of a Chinese herbal plant called Tsai-Fu. It is less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema . The anti-inflammatory action of it are due to an increase in corticosterone caused by the release of arenocorticotropic hormone (ACTH) and a direct effect on the process of inflammation.

target

DPP-IV