Iluzanebart (1-200 mg/kg, ip, single dose) increases microglia proliferation and CSF1R levels in human TREM2 expressing transgenic mice models[1].
| Animal Model: | Human TREM2 expressing transgenic mice models[1] |
| Dosage: | 1-200 mg/kg |
| Administration: | ip, single dose |
| Result: | Increased the number of Ki67 positive microglia, the mean fluorescence intensity (MFI) of microglia with high CSF1R levels and the protein levels of specific chemokines such as IP10 and MIP1α. |
