Ceronapril (SQ 29852) inhibits ACE in male SD rats with ED50s of 0.063 μM/kg and 0.53 μM/kg by IV and PO, respectively[1].
Ceronapril (100 mg/kg; p.o.; single dose or twice daily for 3 days) blocks ACE in peripheral sites in rats[2].
| Animal Model: | Male Sprague-Dawley rats[2] |
| Dosage: | 100 mg/kg |
| Administration: | PO, twice daily for 3 days or single daily dose |
| Result: | Showed clear inhibition of ACE in the 2 circumventricular organs-the subfornical organ and the lamina terminals-but no change in other regions of the brain after chronic treatment. Inhibited ACE in plasma, kidney and lung rapidly (3 hr) after a single administration. Did not inhibit ACE in structures of the brain within the blood-brain barrier, such as the caudate-putamen, choroid plexus, globus pallidus, supraoptic nucleus and paraventricular nucleus of the hypothalamus. |
