O-(Bis(2,2-dimethyl-1-aziridinyl)phosphinyl)-N-hydroxyurethane

AB-182 is an aziridine derivative and antitumor agent.

AB-182 is an aziridine derivative and antitumor agent.AB-182 shows synergistic antitumor effects in conjunction with x-irradiation. Intermediate hydrolysis products of AB-182 may block the repair of x-irradiation-induced breaks in the DNA strands by phosphorylating their free 3'-OH end groups.

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[2] Wodinsky I, Clement J, Swiniarski J, Skura A. Combined therapy with an aziridine derivative NSC 200724 (AB182) and radiation on an experimental leukemia. Int J Radiat Oncol Biol Phys. 1979;5(9):1677-1680. DOI:10.1016/0360-3016(79)90796-x