P-CAB agent 2 hydrochloride (example 1) inhibits histamine (HY-B1204)-induced gastric acid secretion in SD rats[1].
P-CAB agent 2 hydrochloride (600, 2000 mg/kg; p.o.; once) shows no acute toxicity and 600mg/kg shows no significant effect on animal body weight in SD rats[1].
| Animal Model: | 180-220 g, SPF grade, male SD rats[1] |
| Dosage: | 2 mg/kg |
| Administration: | P.o.; once |
| Result: | Inhibited histamine-induced gastric acid secretion with the acid suppression rate of 55.4%. |
