8-Arm Poly(ethylene glycol) succinimidyl carbonate (HG) is a multiarm PEG derivative containing succinimidyl NHS ester groups at the end of each of the eight arms attached to a hexaglycerol core.8-Arm PEG-HG is a PEG-NHS reagent. The derivatives can be used for PEGylation, hydrogels, crosslinking, coating, nanoparticles, polymer-drug conjugates, and implantation. Application areas include tissue engineering, drug delivery formulations, diagnostic assays, pharmaceutical and cosmetic development.