Coformycin is isolated from Nocardia
interforma along with formycin. Coformycin
shows a synergistic effect with
formycin on Yoshida rat sarcoma cells because
of its strong inhibition of adenosine deaminase,
which inactivates formycin. Coformycin, having
a characteristic seven-membered ring base
moiety, is thought to be a typical example of a
“transition-state analog” in the adenosine deaminase
reaction. 2_x0002_-Deoxycoformycin (19b) has
also been isolated also .
ChEBI: An N-glycosyl in which (8R)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol is attached to ribofuranose via a beta-N3-glycosidic bond. compound The
parent of the class of coformycins.
