Pregn-4-en-20-yn-3-one

Itruvone is a intermediate of 17α-ethinylestradiol (EE2) during Fenton oxidation. Itruvone has an antidepressant effect[1][2]. Itruvone is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

[1] Louis Monti. Use of pregn-4-en-20-yn-3-one for the treatment of depressive disorders. Patent WO2014105620 A1.
[2] Li Y, et al. Removal of steroid estrogens from waste activated sludge using Fenton oxidation: influencing factors and degradation intermediates. Chemosphere. 2014 Jun;105:24-30. DOI:10.1016/j.chemosphere.2013.10.043