ChemicalBook Product Catalog API Antineoplastic agents Other antineoplastic Drugs Inebilizumab

Inebilizumab

Chemical Properties

form	Liquid
color	Colorless to light yellow

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Animal Model:	huCD19/CD20 double Tg mice^[2]
Dosage:	0.5, 2, or 10 mg/kg
Administration:	Tail vein injection, once
Result:	Depleted B cells from blood and spleen, B-cell depletion in blood and spleen was maintained for more than 2 weeks after a single 10 mg/kg administration (better than Rituximab). Resulted in a substantial reduction (on average by 91.4% by day 3) in BM B220+muCD19+ B cells. Led to depletion of B cell by mouse macrophages.