ChemicalBook > Product Catalog > API > Other Chemical drugs > Infection Prevention and Control of Epidemic > SODIUM FLUOROACETATE
SODIUM FLUOROACETATE Chemical Properties
- Melting point:200-205 °C (dec.)
- Boiling point:105-106 °C
- vapor pressure Non-volatile
- Water Solubility Very soluble
- Merck 13,4194
- Stability:Stable. Flammable. Risk of explosion above flashpoint.
- CAS DataBase Reference62-74-8(CAS DataBase Reference)
- EPA Substance Registry SystemSodium fluoroacetate (62-74-8)
SODIUM FLUOROACETATE Usage And Synthesis
- Chemical Propertieswhite odourless hygroscopic powder
- Chemical PropertiesSodium fluoroacetate is a fluffy, colorless, odorless, hygroscopic solid (sometimes dyed black).
- UsesPredator elimination (coyotes), rodenticide.
- UsesSodium fluoroacetate is used for rodent control in restricted environments and for the control of the brushtail possum and other wild mammals in some countries.
- General DescriptionA fine, white, odorless, powdered solid. Toxic by ingestion, inhalation and skin absorption. Used as a rodenticide.
- Air & Water ReactionsWater soluble.
- Reactivity ProfileSalts, basic, such as SODIUM FLUOROACETATE, are generally soluble in water. The resulting solutions contain moderate concentrations of hydroxide ions and have pH's greater than 7.0. They react as bases to neutralize acids. These neutralizations generate heat, but less or far less than is generated by neutralization of the bases in reactivity group 10 (Bases) and the neutralization of amines. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
- HazardToxic by ingestion, inhalation, and skin absorption. For use by trained operators only, use has been restricted. Cardiac impairment, central nervous system impairment, and nausea.
- Health HazardSODIUM FLUOROACETATE is super toxic. The probable oral lethal dose in humans is less than 5 mg/kg, or a taste (less than 7 drops) for a 150-lb. person.
- Fire HazardWhen heated to decomposition, SODIUM FLUOROACETATE emits highly toxic fumes of sodium oxide and fluorides. Avoid decomposing heat.
- Agricultural UsesInsecticide, Rodenticide, Wildlife control: A U.S. EPA restricted Use Pesticide (RUP). Not listed for use in EU countries. It is seldom used as an insecticide. Sodium fluoroacetate is primarily used around sewers, ships and warehouses, and in agriculture and by state agricultural departments as bait for rodents and large predators, to control rats, mice, squirrels, prairie dogs, coyotes, rabbits and otherpests. It is seldom used as an insecticide. It is very toxic to birds, domestic animals and wildlife either by consuming the bait or eating poisoned carcasses. It is sometimes used in 1% solutions which are injected into collars which are strapped to the necks of sheep, goats and other livestock that predators are attracted to. Coyotes that puncture the collars are likely to be fatally poisoned by the sodium fluoroacetate as a result.
- Trade nameAI3-08434®; FLUORAKIL® 3; FRATOL®; FURATOL®; RATBANE 1080®; TENEIGHTY®; TL 869®; YASOKNOCK®
- Safety ProfileA deadly human poison by ingestion. Experimental poison by ingestion, skin contact, intraperitoneal, subcutaneous, and intravenous routes. A very highly toxic water-soluble salt used mainly as an immediate-action rodenticide. It is absorbed rapidly by the gastrointestinal tract but slowly by the skin unless the skin is abraded or cut. It operates by blocking the Krebs cycle by formation of fluorocitric acid, which inhbits aconitase. It has an effect on either the cardiovascular or nervous system, or both, in all species and, in some species, the skeletal muscles. Humans have mixed responses, with the cardiac feature predominating. By a duect action on the heart, contractile power is lost, which leads to declining blood pressure. Ventricular premature contractions and arrhythmias are seen in all species, including humans. The central nervous system is directly attacked by sodtum fluoroacetate. In humans, the action on the central nervous system produces epileptiform convulsive seizures followed by severe depression. The dangerous dose for humans is 0.5-2 mg/kg. Other species vary considerably in their response to hs material, with primates and birds being the most resistant and carnivora and rodents being the most susceptible. Most domestic animals show a susceptibility fahng between the two extremes indtcated above. Experimental reproductive effects. When heated to decomposition it emits highly toxic fumes of NazO and F-.
- Potential ExposureA potential danger to those involved in the manufacture, formulation, and application of this highly toxic, immediate-action rodenticide.
- Metabolic pathwaySodium fluoroacetate is toxic to all mammals, especially to dogs (LD50
0.1 mg kg-1) and therefore its use is very restricted. An exception is the
aerial application of baits for the control of the brushtail possum in
New Zealand and of other wild mammals in Australia. Such use is controversial
and has been the impetus for some environmental fate studies
(Eason et al., 1993) and secondary toxicity studies.
The role of fluoroacetate in interfering with citrate metabolism is now classical biochemical toxicology (see below).
- ShippingUN2629 Sodium fluorosilicate, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
- Purification MethodsIt is a free-flowing white HIGHLY TOXIC powder which is purified by dissolving it in ca 4 parts of H2O and the pH is checked. If it is alkaline, add a few drops of FCH2CO2H to make the solution just acidic. Evaporate (fumehood) on a steam bath until crystals start to separate, cool and filter the solid off. More solid can be obtained by adding EtOH to the filtrate. Dry it at 100o in vacuum. The p-nitrobenzyl ester crystallises from EtOH with m 76o. POISONOUS. The free acid interferes with the citric acid cycle. [Saunders & Stacey J Chem Soc 1778 1948, Beilstein 2 IV 446.]
- DegradationSodium fluoroacetate is a stable hygroscopic crystalline solid which is very soluble in water. In the absence of biodegradation it is stable in water.
- IncompatibilitiesIncompatible with alkaline metals and carbon disulfide. Avoid decomposing heat.
- Waste DisposalConsult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. This compound is unstable at temperatures above 110°C and decomposes @ 200°C. Thus, careful incineration has been suggested as a disposal procedure. According to their procedure, the produce should be mixed with large amounts of vermiculite, sodium bicarbonate, and sand-soda ash. Slaked lime should also be added to the mixture. Two incineration procedures for this mixture are suggested. The better of these procedures is to burn the mixture in a closed incinerator equipped with an afterburner and an alkali scrubber. The other procedure suggests that the mixture be covered with scrap wood and paper in an open incinerator. (The incinerator should be lighted by means of an excelsior train).
SODIUM FLUOROACETATE Preparation Products And Raw materials
- SODIUM PERFLUOROOCTANOATE Sodium chlorodifluoroacetate TRIFLUOROACETIC ACID SODIUM SALT, [1-14C] SODIUM HEPTAFLUOROBUTYRATE SODIUM TRIFLUOROACETATE-1-13C SODIUM DIFLUOROACETATE SODIUM PENTAFLUOROPROPIONATE SODIUM FLUOROACETATE SODIUM IODOFLUOROACETATE 2,2,3,3,4,4,5,5,6,6,7,7-DODECAFLUOROHEPTANOIC ACID, SODIUM SALT SODIUM FLUOROACETATE, [2-14C] FLUOROACETIC ACID SODIUM SALT, [1-14C] SODIUM CHLOROFLUOROACETATE FLUOROACETIC ACID, SODIUM SALT, [3H]- SODIUM BROMOFLUOROACETATE SODIUM PERFLUOROHEXANOATE SODIUM HEXAFLUOROGLUTARATE SALOR-INT L120243-1EA