N-Ethylidene tert-butylamine

N-Ethylidene-tert-butylamine can be used for general synthetic approach of natural products empowered by potentially biomimetic ring expansion.

Acetaldehyde N-t-Butylimine is prepared by condensation of freshly distilled Acetaldehyde with t-Butylamine without solvent.  

N-Ethylidene t-butylamine is very sensitive to hydrolysis; store in closed vessels under an inert atmosphere in the refrigerator. Use of the freshly distilled reagent is recommended. Use in a fume hood.