3-(2-Ethylphenyl)-2-mercaptoquinazolin-4(3H)-one

Thioxodihydroquinazolinone-19 is an inducer of apoptotic cell death in platinum-resistant A2780cis human ovarian cancer cells. It acts by exhibiting a strong inhibitory effect in ovarian CSC-LCs in combination with cisplatin.

Anticancer agent 173 (compound 19) is a potent thioxodihydroquinazolinone analogs when combined with platinum drugs in inducing apoptotic cancer cells death[1].

[1] Jing Ma, et al. Combination of a thioxodihydroquinazolinone with cisplatineliminates ovarian cancer stem cell-like cells (CSC-LCs) andshows preclinical potential. Oncotarget. 2017 Dec 26;9(5):6042-6054. DOI:10.18632/oncotarget.23679