TRIETHYL 4-PHOSPHONOCROTONATE

CLEAR LIGHT YELLOW LIQUID

Reactant for:

• Iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase
• Stereoselective preparation of C1-C19 fragment of macrolide antibiotic aplyronine A using diastereoselective Nozaki-Hiyama-Kishi coupling reactions
• Orally bioavailable GPR40 agonist synthesis
• Synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2
• Preaparation of mGlu4R agonists
• Dearomatizing cyclization of nicotinyl-substituted esters and ketones

Triethyl 4-phosphonocrotonate is used as a reactant for iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase, orally bioavailable GPR40 agonist synthesis, preparation of mGlu4R agonists and synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.