Histone H3K14Ac/H3K23Ac (1-24)-GGK-biotin (trifluoroacetate salt)

Histone H3K14Ac/H3K23Ac (1-24)-GGK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 2-25 of the human histone H3 sequence. It is acetylated at lysine 14 and lysine 23 and biotinylated via a C-terminal GGK linker. Acetylation of H3K14 or H3K23 is associated with transcriptional activation and H3K14 acetylation is required for trimethylation of H3K4.1,2 H3K23 acetylation is decreased in wild-type but increased in uninephrectomized db/db mouse kidney.3WARNING This product is not for human or veterinary use.

[1] SAMUEL T KEATING. Epigenetics in diabetic nephropathy, immunity and metabolism.[J]. Diabetologia, 2018: 6-20. DOI: 10.1007/s00125-017-4490-1
[2] SHIMA NAKANISHI. A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation[J]. Nature Structural & Molecular Biology, 2008, 15 8: 881-888. DOI: 10.1038/nsmb.1454
[3] SUFYAN G SAYYED. Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10.[J]. Nephrology Dialysis Transplantation, 2010, 25 6: 1811-1817. DOI: 10.1093/ndt/gfp730