Atripla contains 3 HIV-1 medicines in one pill: SUSTIVA (efavirenz, E425000), EMTRIVA (emtricitabine, E525000) and VIREAD (tenofovir disoproxil fumarate, T018505). This combination works to help lower the amount of HIV-1 in the blood (called viral load) by interfering with the way HIV makes copies of itself (called viral replication). Lowering the amount of HIV-1 in the blood may also help increase the number of T-cells (CD4+ cells).