cerliponase alfa

Tripeptidyl aminopeptidase (Cerliponase alfa) removes tripeptides from the free NH, terminus of longer peptides. Tripeptidyl aminopeptidase has the potential for the research of CLN2 disease[1][2].

[1] Schulz A, et al. Study of Intraventricular Cerliponase Alfa for CLN2 Disease. N Engl J Med. 2018 May 17;378(20):1898-1907. DOI:10.1056/NEJMoa1712649
[2] Blw RM, et al. Tripeptidyl aminopeptidase in the extralysosomal fraction of rat liver. J Biol Chem. 1983 Oct 10;258(19):11622-8. PMID:6352701