4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE

Product Name4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE
CAS5122-36-1
MFC5H7N5O
MW153.14
EINECS200-258-5
MOL File5122-36-1.mol

Chemical Properties

Melting point	224-226 °C
Boiling point	536.1±50.0 °C(Predicted)
Density	1.575±0.06 g/cm3(Predicted)
storage temp.	−20°C
pka	12.35±0.70(Predicted)
form	Solid
color	Off-white to light yellow

Safety Information

WGK Germany

MSDS

Provider	Language
SigmaAldrich	English

Usage And Synthesis

Uses

FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases[1][2][3].

Definition

ChEBI: A member of the class of aminopyrimidines that is 4,6-diaminopyrimidine bearing an additional formamido substituent at position 5. A DNA lesion formed when DNA exposed to ionising radiation.

in vivo

The nuclear DNA damage by oxygen-derived radicals is increased in Alzheimer's disease and support the concept that the brain is under increased oxidative stress in Alzheimer's disease^[1].

IC 50

Human Endogenous Metabolite

References

[1] Gabbita SP, et al. Increased nuclear DNA oxidation in the brain in Alzheimer's disease. DOI:10.1046/j.1471-4159.1998.71052034.x
[2] Cysewski P, et al. Theoretical description of the coding potential of diamino-5-formamidopyrimidines. Z Naturforsch C J Biosci. 1999 Mar-Apr;54(3-4):239-45. DOI:10.1515/znc-1999-3-414
[3] Lee SH, et al. A rapid and sensitive method for quantitation of nucleosides in human urine using liquid chromatography/mass spectrometry with direct urine injection. Rapid Commun Mass Spectrom. 2004;18(9):973-7. DOI:10.1046/j.1471-4159.1998.71052034.x