9-Oxo-15s-hydroxy-prosta-5z,8(12),13e,17z-tetraen-1-oic acid

Prostaglandin B₃ (PGB₃) is a non-enzymatic dehydration product resulting from the treatment of Prostaglandin E₃ (PGE₃) with strong base. In a structure-activity binding study to determine the affinity of various prostaglandins to human PPARγ, PGB₃ exhibited a K_i value greater than 1 mM. In contrast, PGB₁ and PGB₂ showed significantly higher affinity for PPARγ, with K_i values of 26 and 77 μM, respectively, the same assay.

Prostaglandin B3 (PGB3) is a member of the class of prostaglandins B and a secondary alcohol. PGB3 exhibits a rather low affinity to human PPARγ with a Ki value greater than 1 mM compared with Ki values of 26.28 ± 8.7 μM for PGB1 and 77 ± 37.7 μM for PGB2[1].

PPARγ

[1] Ferry G, et al. Binding of prostaglandins to human PPARgamma: tool assessment and new natural ligands. Eur J Pharmacol. 2001 Apr 6;417(1-2):77-89. DOI:10.1016/s0014-2999(01)00907-4