6,9alpha-Methylene-9beta-methyl-11alpha,15s-dihydroxy-prosta-5z,13e-dien-1-oic acid, calcium salt

Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI₂. Ciprostene exhibits biological activity similar to PGI₂, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 μg/kg/min. In addition, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID₅₀ values of 9.1 μg/kg/min and 60 ng/ml, respectively.

Platelet aggregation inhibitor.

[1] G. ALLAN. The cardiovascular and platelet actions of 9β-methyl carbacyclin (ciprostene), a chemically stable analogue of prostacyclin, in the dog and monkey[J]. British Journal of Pharmacology, 1985, 85 2: 547-555. DOI: 10.1111/j.1476-5381.1985.tb08892.x
[2] PAUL A. ARISTOFF  Allen W H  Paul D Johnson. Synthesis of 9-substituted carbacyclin analogs[J]. The Journal of Organic Chemistry, 1983, 48 26: 5341-5348. DOI: 10.1021/jo00174a035