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GUANETHIDINE HEMISULFATE

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GUANETHIDINE HEMISULFATE Basic information
GUANETHIDINE HEMISULFATE Chemical Properties
  • Melting point:255-265°C
  • Density 1.1052 (rough estimate)
  • refractive index 1.7400 (estimate)
  • storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
  • Merck 4560
  • CAS DataBase Reference60-02-6
Safety Information
  • Safety Statements 24/25
  • RTECS MF3240000
GUANETHIDINE HEMISULFATE Usage And Synthesis
  • Chemical PropertiesWhite Solid
  • OriginatorIsmelin,Ciba,US,1960
  • UsesAntihypertensive; antiglaucoma
  • DefinitionChEBI: A organic sulfate salt composed of two molecules of guanethidine and one of sulfuric acid.
  • Manufacturing Process13.6 grams of chloroacetyl guanide is added while stirring to a solution of 22.6 grams of heptamethylene imine in 200 ml of benzene. After warming for 1 hour, and then cooling, the solution is filtered and the filtrate concentrated under reduced pressure. The residue, containing the 2-(1-N,N-heptamethylene-imino)-aceticacid guanide, is suspended in tetrahydrofuran and added to a refluxing solution of 6 grams of lithium aluminum hydride in tetrahydrofuran. After completion of the reaction, the excess of lithium aluminum hydride is decomposed by adding water, then aqueous sodium hydroxide. The solid material is filtered off, the filtrate is acidified with sulfuric acid and the 2-(1-N,N-heptamethylene-imino)-ethyl-guanidine sulfate can be recovered and recrystallized from aqueous ethanol, MP 276° to 281°C (with decomposition).
  • Therapeutic FunctionAntihypertensive
GUANETHIDINE HEMISULFATE(60-02-6)Related Product Information
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