6-KETO PROSTAGLANDIN F1ALPHA-D4

6-keto Prostaglandin F_1α-d₄ (6-keto PGF_1α-d₄) contains four deuterium atoms at the 3, 3'', 4, and 4'' positions. It is intended for use as an internal standard for the quantification of 6-keto PGF_1α by GC- or LC-MS. 6-keto PGF_1α is the inactive, non-enzymatic hydrolysis product of PGI₂. 6-keto PGF_1α serves as a useful marker of PGI₂ biosynthesis in vivo. When [³H]-PGI₂ is injected into healthy human males, 6.6% of the radioactivity is recovered from urine as [³H]-6-keto PGF_1α.