1189561-66-7
1189561-66-7 性质
| 储存条件 | Store at -20°C, protect from light, stored under nitrogen |
|---|---|
| 溶解度 | DMSO：50mg/mL（86.41mM）；水：< 0.1 mg/mL（不溶） |
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
1189561-66-7 用途与合成方法
|
Bcl-2
|
Bcl-xL
|
The natural racemic Gossypol has two enantiomers, namely the (-)-Gossypol and (S)-Gossypol ((+)-Gossypol) enantiomers. (+)-Gossypol and (-)-Gossypol binds to Bcl-2 or Bcl-xL with similar binding affinities. (-)-Gossypol is more potent than (+)-Gossypol in inhibition of cell growth and induction of apoptosis. The racemic form and each of the enantiomers of Gossypol are tested against UM-SCC-6 and UM-SCC-14A in 6-day MTT assays. (-)-Gossypol exhibits greater growth inhibition relative to (±)-Gossypol than (+)-Gossypol in both cell lines tested (P<0.001). An intermediate growth inhibitory effect is observed with (±)-Gossypol but this effect is only observed at the higher dose of Gossypol (10 μM, P<0.0001).
1189561-66-7 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-15464D | 5 mg | 875 | ||
| 2024-11-08 | HY-15464D | 1189561-66-7 | 1189561-66-7 | 10mg | 1400 |
