4-fluorobenzoic boric acid and 2-bromothiophene, Pd catalyst are added in organic solvent and dissolves, obtain material 3, wherein: 4-fluorine Phenylboric acid molar concentration in organic solvent is 0.5mol/L～2mol/L, and 4-fluorobenzoic boric acid with the mol ratio of 2-bromothiophene is 1:1.0～1:1.5,4-fluorobenzoic boric acid is 1:0.005～1:0.1 with the mol ratio of catalyst；Using material 3 with as material 4 Inorganic base aqueous solution carries out pre-incubation respectively to being 1:1.0～1 according to the mol ratio of 4-fluorobenzoic boric acid Yu alkali after reaction temperature: The mode of 3.0 mixes, and reacts under conditions of 50 ℃～80 ℃, then carries out post processing and obtains 2-(4-fluorophenyl) Thiophene.
