11-DEOXY-16,16-DIMETHYL PROSTAGLANDIN E2

11-deoxy-16,16-dimethyl PGE₂ is a stable synthetic analog of PGE₂. It is an agonist for both EP₂ and EP₃ receptors. It is an effective inhibitor of gastric acid secretion and ulcer formation in the rat, with ED₅₀ values of 1 mg/kg and 0.021 mg/kg respectively. It is 900 times more potent than PGF_2α in the contraction of human respiratory tract smooth muscle in vitro.

AY 24609 is an analogue of PGE2 and a selective EP2 and EP3 receptors agonist. It also inhibits gastric acid secretion and ulcer formation in rat.

ChEBI: 11-Deoxy-16,16-dimethyl-PGE2 is a prostanoid.

EP2; EP3

[1] R.F. PARROTT  S. V V. Effects of centrally administered prostaglandin EP receptor agonists on febrile and adrenocortical responses in the prepubertal pig[J]. Brain Research Bulletin, 1996, 41 2: Pages 97-103. DOI: 10.1016/0361-9230(96)00156-6
[2] LIPPMANN W. Inhibition of gastric acid secretion and ulcer formation in the rat by orally-administered 11-deoxyprostaglandin analogues: 15-hydroxy-16,16-dimethyl-9-oxoprost-5,13-dienoic acids[J]. Prostaglandins, 1974, 7 3: Pages 231-246. DOI: 10.1016/0090-6980(74)90007-0