| Result: | Pharmacokinetics of GNF179 in nave Balb/C mice.
| Dose | AUC(0-∞)
(hrs*μM) | AUC/dose | t1/2
(hrs) | MRT
(hrs) | CL
(ml/min/kg) | Vss
(L/kg) | C0 or Cmax
(μM) | F (%) | | 3 mg/kg i.v. | 8.88 | 3.0 | 8.9 | 9.0 | 22 | 11.8 | 6.1 | nd | | 20 mg/kg p.o. | 20.70 | 1.0 | 8.4 | nd | nd | nd | 1.2 | 58 |
AUC, Area Under the Curve; T1/2, half life; CL, clearance; VSS, steady-state volume of distribution; C0, initial concentration; Cmax maximum concentration; F, fraction of dose absorbed; hrs, hours; nd, not determined.
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