N-Hydroxy-MDA Hydrochloride

3,4-Methylenedioxyamphetamine (MDA) is psychedelic and entactogenic drug that is scheduled as a controlled substance in the United States. N-hydroxy-MDA is an analog of MDA (, hydrochloride form) which inhibits reuptake of noradrenaline (IC₅₀ = 87.8 μM) more effectively than serotonin (IC₅₀ = 215 μM). Like MDA, N-hydroxy-MDA is regulated in the United States. This product is intended for forensic and research applications.

N-Hydroxy-MDA is an 3,4-methylenedioxymethamphetamine (M303985) analogue and was studied as a inhibitor of [3H]noradrenaline and [3H]5-HT transport in mammalian cell lines.

[1] T MONTGOMERY. Comparative potencies of 3,4-methylenedioxymethamphetamine (MDMA) analogues as inhibitors of [3H]noradrenaline and [3H]5-HT transport in mammalian cell lines[J]. British Journal of Pharmacology, 2009, 152 7: 1121-1130. DOI: 10.1038/sj.bjp.0707473
[2] MATTHEW J BAGGOTT. Investigating the mechanisms of hallucinogen-induced visions using 3,4-methylenedioxyamphetamine (MDA): a randomized controlled trial in humans.[J]. ACS Applied Bio Materials, 2010: e14074. DOI: 10.1371/journal.pone.0014074