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Adelmidrol Structure

Adelmidrol

Chemical Properties

Melting point 132-134℃
Boiling point 596.4±45.0 °C(Predicted)
Density  1.097±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO:77.5(Max Conc. mg/mL);282.47(Max Conc. mM)
Ethanol:28.0(Max Conc. mg/mL);102.06(Max Conc. mM)
Water:55.0(Max Conc. mg/mL);200.47(Max Conc. mM)
pka 14.19±0.10(Predicted)
form  Solid
color  White to off-white
InChI InChI=1S/C13H26N2O4/c16-10-8-14-12(18)6-4-2-1-3-5-7-13(19)15-9-11-17/h16-17H,1-11H2,(H,14,18)(H,15,19)
InChIKey PAHZPHDAJQIETD-UHFFFAOYSA-N
SMILES C(NCCO)(=O)CCCCCCCC(NCCO)=O

Usage And Synthesis

target

NF-κB

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COX-2

PPARγ

References
[1] Cordaro M, et al. Adelmidrol, a Palmitoylethanolamide Analogue, as a New Pharmacological Treatment for the Management of Inflammatory Bowel Disease. BIOCHEMICAL PHARMACOLOGY, 2016; 90: 549-561
[2] Fusco R, et al. Adelmidrol: A New Promising Antioxidant and Anti-Inflammatory Therapeutic Tool in Pulmonary Fibrosis. Antioxidants, 2020; 9.
[3] Guida F, et al. Targeting Neuroinflammation in Osteoarthritis with Intra-Articular Adelmidrol. 2022; 12.

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