CP 316311 is a potent and selective CRF1 receptor antagonist with IC50 of 6.8 nM.
in vitro
CP 316311 fully antagonizes CRF-stimulated adenylate cyclase activity in rat cortex and at human CRF1 receptors endogenously expressed in IMR32 cells with apparent K i values of 7.6 and 8.5 nM, respectively. < /p>