SK1-I
中文名称:SK1-I
英文名称:SK1-I
CAS号:1072443-89-0
分子式:C17H27NO2
分子量:277.41
EINECS号:
Mol文件:1072443-89-0.mol
![SK1-I 结构式](https://img.chemicalbook.com/CAS/20211123/GIF/1072443-89-0.gif)
SK1-I 性质
沸点 | 452.9±45.0 °C(Predicted) |
---|---|
密度 | 1.039±0.06 g/cm3(Predicted) |
形态 | 白色固体。 |
酸度系数(pKa) | 13.57±0.20(Predicted) |
颜色 | 米白色至浅黄色 |
SK1-I 用途与合成方法
SK1-I (BML-258) 是鞘氨醇的类似物,是同功酶特异性 SPHK1 竞争抑制剂,Ki 值为 10 µM。SK1-I (BML-258) 具有良好的水溶性。SK1-I (BML-258) 对 SPHK2,PKCα,PKCδ,PKA,AKT1,ERK1,EGFR,CDK2,IKKβ 或 CamK2β 无活性。SK1-I (BML-258) 增强自噬并具有抗肿瘤活性。
Ki: 10 µM (SPHK1)
SK1-I (0-10 μM; 24 hours) attenuates cancer cell growth and survival in a TP53-dependent manner in HCT116 cells and HCT116 cells bearing
TP53
null cancer.
SK1-I (0-20 μM; 12 hours) induces more CASP3 cleavage in HCT116 cells, compared to HCT116 cells lacking TP53, leading to a hallmark of apoptosis.
Cell Viability Assay
Cell Line: | HCT116 cells and HCT116 cells bearing TP53 null cancer |
Concentration: | 0 µM, 2.5 µM, 5 µM, 7.5 µM, 10 µM |
Incubation Time: | 24 hours |
Result: | Decreased cancer cell growth and survival. |
Western Blot Analysis
Cell Line: | HCT116 cells and HCT116 cells bearing TP53 null cancer |
Concentration: | 0 µM, 5 µM, 10 µM, 20 µM |
Incubation Time: | 12 hours |
Result: | Induced more CASP3 cleavage in HCT116 cells, compared to HCT116 cells lacking TP53. |
Pre-treatment with SK1-I (BML-258; intraperitoneal (i.p.) injection; once; 24 hours prior to baseline mean arterial blood pressure (MAP) measurement; 75 mg/kg) before anandamide (i.v. injection; two doses; 1 and 10 mg/kg) significantly decreases the hypotensive response.
Animal Model: | Male C57BL/6 mice (24 ± 3.5 g) |
Dosage: | 75 mg/kg |
Administration: | Intraperitoneal (i.p.) injection; once; 24 hours prior to baseline MAP measurement |
Result: | Significantly lowered baseline mean arterial blood pressure (MAP). |
SK1-I 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-04-30 | HY-119016 | 1 mg | 1590 | ||
2024-04-30 | HY-119016 | SK1-I | 1072443-89-0 | 5mg | 3500 |
SK1-I供应商 更多
上海一飞生物科技有限公司
联系电话:021-65675885 18964387627
产品介绍:
英文名称:SK1-I
CAS:1072443-89-0
纯度:98% (HPLC)
包装信息:10mg
备注:试剂级
上海源溪生物科技有限公司
联系电话:021-58447131 13564518121
产品介绍:
英文名称:SK1-I
CAS:1072443-89-0
纯度:98% HPLC
包装信息:100mg,250mg,1g
TargetMol中国(陶术生物)
联系电话: 15002134094
产品介绍:
英文名称:SK1-I
CAS:1072443-89-0
纯度:详情请点击官网
包装信息:1 mg
备注:试剂级