Fenbendazole-d3

Fenbendazole-d₃ is intended for use as an internal standard for the quantification of fenbendazole by GC- or LC-MS. Fenbendazole is a benzimidazole anthelmintic. It is active against Giardia in vitro (IC₅₀ = 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection. It also activates HIF-1α and prevents oxidative stress-induced death in primary neurons in vitro.

Labelled Fenbendazole (F246750). An anthelmintic (Nematodes).

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[3] HOSSEIN ALEYASIN. Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin.[J]. Antioxidants & redox signaling, 2015, 22 2: 121-134. DOI: 10.1089/ars.2013.5595