ChemicalBook Product Catalog Natural Products Flavonoids Catechin 7-o-beta-D-xyloside

Catechin 7-o-beta-D-xyloside

Product NameCatechin 7-o-beta-D-xyloside
CAS65597-47-9
MFC21H24O11
MW452.41
EINECS
MOL File65597-47-9.mol

Chemical Properties

Melting point	165-170 °C(Solvent: Methanol)
Boiling point	819.587±65.00 °C(Press: 760.00 Torr)(predicted)
Density	1.670±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
form	Solid
pka	9.269±0.60(predicted)
color	White to off-white

Usage And Synthesis

Uses

Catechin 7-O-beta-D-glucopyranoside is an orally active natural product found in Ulmus davidiana and Paeonia obovata. Catechin 7-O-β-D-glucopyranoside shows antioxidant and anti-inflammatory activities, and attenuates mitochondrial dysfunction. Catechin 7-O-beta-D-glucopyranoside can be used in intestinal inflammatory disease research[1][2][3].

Definition

ChEBI: (+)-catechin 7-O-beta-D-xyloside is a monosaccharide derivative that is (+)-catechin substituted by a beta-D-xylopyranosyl moiety at position 7 via a glycosidic linkage. It is a beta-D-xyloside and a monosaccharide derivative. It is functionally related to a (+)-catechin.

in vivo

Catechin 7-O-β-D-glucopyranoside (intraperitoneal injection; 10 mg/kg; once) treatment shows mild protective effect against lethality induced by LPS/D-GalN^[1].
Catechin 7-O-β-D-glucopyranoside (oral administration; 10 mg/kg; once daily; 7 d) treatment prevents intestinal inflammatory damages in TNBS model of rat colitis^[2].

Animal Model:	Mice injected with LPS/D-GalN^[1]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; 10 mg/kg; once
Result:	Showed 80% LPS/DGalN-induced lethality in mice.

Animal Model:	Rat model of trinitrobenzenesulfonic acid (TNBS)-induced colitis ^[2]
Dosage:	10 mg/kg
Administration:	Oral administration; 10 mg/kg; once daily; 7 days
Result:	Suppressed body weight loss and intestinal inflammatory damages in TNBS-induced colitic rats. Reduced myeloperoxidase activity and malondialdehyde level, but increased glutathione level in the TNBS colitic rats.

References

[1] Zheng MS, et al. Protective constituents against sepsis in mice from the root barks of Ulmus davidiana var. japonica. Arch Pharm Res. 2011 Sep;34(9):1443-50. DOI:10.1007/s12272-011-0905-6
[2] Kook SH, et al. Catechin-7-O-β-D-glucopyranoside isolated from the seed of Phaseolus calcaratus Roxburgh ameliorates experimental colitis in rats. Int Immunopharmacol. 2015 Dec;29(2):521-527. DOI:10.1016/j.intimp.2015.10.003
[3] Kim KC, et al. Cytoprotective effects of catechin 7-O-β-D glucopyranoside against mitochondrial dysfunction damaged by streptozotocin in RINm5F cells. Cell Biochem Funct. 2010 Dec 2;28(8):651-60. DOI:10.1002/cbf.1703

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