FRESELESTAT
![FRESELESTAT 结构式](https://img.chemicalbook.com/CAS/GIF/208848-19-5.gif)
FRESELESTAT 性质
熔点 | 151-153oC |
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密度 | 1.32±0.1 g/cm3(Predicted) |
储存条件 | -20°C Freezer |
溶解度 | 可溶于DMSO(少许)、甲醇(少许) |
酸度系数(pKa) | 12.43±0.46(Predicted) |
形态 | 固体 |
颜色 | 灰白色至浅黄色 |
FRESELESTAT 用途与合成方法
Ki: 12.2 nM (Neutrophil elastase)
Simulated extracorporeal circulation is established by recirculating fresh heparinized (3.75 U/mL) human blood for 120 minutes in a membrane oxygenator and a roller pump with and without 1.0 μM of Freselestat (ONO-6818). Neutrophil elastase levels are significantly lower in the Freselestat group. Freselestat significantly reduces interleukin 8 and C5b-9 production. Freselestat does not modulate changes of CD11b and L-selectin during recirculation.
Freselestat (ONO-6818; 10-100 mg/kg; oral administration; daily; for 8 weeks) treatment attenuates dose-dependently HNE-induced increases in lung myeloperoxidase activity, hemoglobin, and neutrophil count in bronchoalveolar lavage fluid. ONO-6818 inhibits acute lung injury induced by HNE by minimizing lung hemorrhage and accumulation of neutrophils in the lung.
Animal Model: | Male Wistar rats (228 g) induced by human neutrophil elastase (HNE) |
Dosage: | 10 mg/kg, 100 mg/kg |
Administration: | Oral administration; daily; for 8 weeks |
Result: | Attenuated dose-dependently HNE-induced increases in lung myeloperoxidase activity, hemoglobin, and neutrophil count in bronchoalveolar lavage fluid. |
FRESELESTAT 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024-04-30 | HY-15652 | 10 mg | 3100 | ||
2024-04-30 | HY-15652 | 25 mg | 6200 |