yclopropanecarboxylic acid N-[4-[[4-chloro-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-yl]sulfanyl]phenyl]amide

639090-53-2

31230-17-8

639090-55-4

[4-(4,6-Dichloropyrimidin-2-ylsulfonyl)phenyl]methanaminocyclopropanecarboxylic acid (3.0 g, 8.85 mmol) and 3-amino-5-methyl-1H-pyrazole (0.94 g, 9.7 mmol) were mixed in DMF (16 mL) with diisopropylethylamine (1.25 g, 9.7 mmol) and potassium iodide (1.76 g, 10.6 mmol). The reaction mixture was stirred at 50 °C for 6 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure and the residue was purified by recrystallization from ethyl acetate. The target product N-[4-[[4-chloro-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-yl]sulfonyl]phenyl]aminocyclopropanecarboxylic acid (2.0 g, 91% yield) was obtained as a white solid.LC-MS (m/z): 401 [M + 1]+; 1H NMR (DMSO-d6) δ: 0.82 (d, J = 6.6 Hz, 4H) ), 1.85 (m, 1H), 1.99 (s, 1H), 5.24 (bs, 1H), 6.47 (bs, 1H), 7.55 (m, 2H), 7.71 (m, 2H), 10.22 (s, 1H), 11.95 (s, 1H).