ChemicalBook Product Catalog API Nervous system drugs Antidepressants, Antimanics drugs PAROXETINE-D4 HCL

PAROXETINE-D4 HCL

Product NamePAROXETINE-D4 HCL
CAS110429-35-1
MFC19H23ClFNO4
MW383.84
EINECS000-000-0
MOL File110429-35-1.mol

Chemical Properties

Melting point	121-131 C
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Slightly soluble in water, freely soluble in methanol, sparingly soluble in ethanol (96 per cent) and in methylene chloride.
form	powder
color	white
λmax	292nm(H2O)(lit.)
Merck	14,7043
InChI	InChI=1/C19H20FNO3.ClH.H2O/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;/h1-6,9,14,17,21H,7-8,10-12H2;1H;1H2/t14-,17-;;/s3
InChIKey	QRQSGFFISBKLMZ-BGBHMREKNA-N
SMILES	C([C@@H]1CNCC[C@H]1C1C=CC(F)=CC=1)OC1C=CC2OCOC=2C=1.Cl.O \|&1:1,6,r\|
CAS DataBase Reference	110429-35-1

Safety Information

Hazard Codes	F,C,Xn
Risk Statements	11-34-36/37/38-22
Safety Statements	16-26-36/37/39-45-36
RIDADR	UN 3077 9 / PGIII
WGK Germany	3
RTECS	TM4569320
HazardClass	IRRITANT
HS Code	29349990
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 1 Eye Irrit. 2 Skin Sens. 1 STOT SE 3

Usage And Synthesis

Chemical Properties

White or almost white, crystalline powder.

Uses

Antidepressant;5-HT uptake inhibitor

Uses

Paroxetine hydrochloride hemihydrate has been used: as an antidepressant to study its effects on neural stem cells (NSCs) from embryonic rat hippocampus in vitro; as a CYP 2D6 inhibitor to study its effects on the in vitro?production by human recombinant CYP 2D6 of the phenolic metabolites; as an antidepressant to study its effects on the expression of pituitary adenylate cyclase activating polypeptide (PACAP), its receptors and brain-derived neurotrophic factor (BDNF) in rat primary hippocampal neurons

Uses

Paroxetine Hydrochloride, is a selective serotonin reuptake inhibitor (SSRI) antidepressant used to treat depression, panic attacks, obsessive-compulsive disorder (OCD), anxiety disorders, post-traumatic stress disorder, and a severe form of premenstrual syndrome (premenstrual dysphoric disorder).

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Paroxetine hydrochloride hemihydrate is one of the most potent and selective of the selective serotonin reuptake inhibitors (SSRI); antidepressant

in vivo

Paroxetine treatment obviously attenuates the symptoms of CIA rats. Paroxetine treatment clearly prevents the histological damage of joints and alleviates T cells infiltration into synovial tissue. Paroxetine reveals a strong effect on inhibiting CX3CL1 production in synovial tissues^[1]. Paroxetine (20 mg/kg/day) reduces the myocyte cross-sectional area in rat and ROS formation in the remote myocardium. Paroxetine reduces the susceptibility to ventricular tachycardia. Paroxetine treatment following MI decreases LV remodeling and susceptibility to arrhythmias, probably by reducing ROS formation^[2]. In CCI paroxetine-treated group, paroxetine (10 mg/kg, i.p.) produces hyperalgesia at days 7 and 10 (P<0.01), but a decrease in pain behavior is seen at day 14. Moreover, paroxetine (10 mg/kg) significantly attenuates tactile hypersensitivity when compared to CCI vehicle-treated group^[5].

PAROXETINE-D4 HCL

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