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CLOXAZOLAM Basic information
CLOXAZOLAM Chemical Properties
  • Melting point:202-204° (dec)
  • Boiling point:172°C (rough estimate)
  • Density 1.4125 (rough estimate)
  • refractive index 1.6100 (estimate)
  • pka12.70±0.40(Predicted)
  • CAS DataBase Reference24166-13-0
Safety Information
  • RIDADR 3249
  • HazardClass 6.1(b)
  • PackingGroup III
  • ToxicityLD50 in mice (g/kg): 3.3 orally; >2.0 i.p. (Kamioka)
CLOXAZOLAM Usage And Synthesis
  • OriginatorSepazon,Sankyo,Japan,1974
  • UsesCLOXAZOLAM is a benzodiazepine derivative with anxiolytic, hypnotic and antihypertensive properties used as an anti-anxiety drug. It is metabolized into the active metabolite Delorezepam (D230675). Controlled Subs tance.
  • Manufacturing ProcessAs described in US Patent 3,772,371: To a solution of 5.8 g of 5-chloro-2- bromoacetylamino-o-chlorobenzophenone in 120 ml of ethanol were added 0.95 g of ethanolamine and 1.3 g of sodium acetate. The resulting mixture was heated under reflux for 16 hours.
    After completion of the reaction, the solvent was distilled off and the residue was extracted with dichloromethane. The extract was washed with water, dried over anhydrous sodium sulfate and the solvent was distilled off to give 3.25 g of the desired product melting at 202° to 204°C with decomposition.
  • Therapeutic FunctionTranquilizer
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