N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine

CZC-8004 (916603-07-1) is a pan-specific kinase inhibitor. May be coupled to sepharose via its amino-side chain for affinity chromatography applications1.

A novel enzyme-interacting compounds using immobilized broad-spectrum ligands

CZC-8004 is an aminopyrimidine that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES. It inhibits these kinases at low micromolar concentrations and can be immobilized to capture and purify these enzymes.

ChEBI: CZC8004 is an aminopyrimidine and an organofluorine compound. It has a role as a protein kinase inhibitor.

[1] SYLVESTER R. KLUTCHKO. 2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity[J]. Journal of Medicinal Chemistry, 1998, 41 17: 3276-3292. DOI:10.1021/jm9802259