1-Bromo-2-ethyl-4-methoxy-benzene

10568-38-4

34881-44-2

General procedure for the synthesis of 1-bromo-2-ethyl-4-methoxybenzene from 1-ethyl-3-methoxybenzene: 3-ethylanisole (50 g, 0.3676 mol) and N-bromosuccinimide (72 g, 0.4 mol) were dissolved in acetonitrile (1 L), and the reaction was stirred for 8 hours at room temperature protected from light. After completion of the reaction, the reaction mixture was concentrated at a temperature below 40 °C. The concentrated residue was redissolved in carbon tetrachloride and filtered to remove insoluble material. The filtrate was concentrated and finally the target product was obtained by fractional purification. A light yellow liquid product of 35 g was obtained in 43% yield.