丁硫氨酸-亚砜亚胺
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丁硫氨酸-亚砜亚胺 性质
熔点 | 224-228 °C (dec.) |
---|---|
沸点 | 382.3±52.0 °C(Predicted) |
密度 | 1.29 |
折射率 | 1.6300 (estimate) |
储存条件 | -20°C |
溶解度 | 在水中的溶解度50 mg/mL,澄清,无色至淡黄色 |
形态 | 细粉 |
颜色 | 白色 |
生物来源 | synthetic (organic) |
水溶解性 | water: 50mg/mL, clear to slightly hazy, colorless to faintly yellow |
BRN | 2367136 |
稳定性 | 溶液不稳定,必须现配现用。 |
CAS 数据库 | 83730-53-4 |
丁硫氨酸-亚砜亚胺 用途与合成方法
γ-glutamylcysteine synthetase.
L-Buthionine-(S,R)-sulfoximine (BSO: 50 μM) treatment for 48 hr results in a 95% decrease in ZAZ and M14 melanoma cell line GSH levels, and a 60% decrease in GST enzyme activity. GST-π protein and mRNA levels are significantly reduced in both cell lines. L-Buthionine-(S,R)-sulfoximine (BSO) induces oxidative stress in a cell by irreversibly inhibiting g-glutamylcysteine synthetase, an essential enzyme for the synthesis of glutathione (GSH).
The average number of eye-spots (mean±SEM) is 5.36±0.29 (n=46), 7.79±0.45 (n=34) and 8.78±0.61 (n=32) in untreated controls, 2 mM L-Buthionine-(S,R)-sulfoximine (BSO) and 20 mM BSO treated mice, respectively. The 2 mM BSO treatment results in ~30% more eye-spots, and the 20 mM treatment results in 40% more eye-spots compared with untreated mice. It is showed that BSO causes an elevated frequency of DNA deletions during mouse development. BSO treatment reduced GSH concentration in mouse fetuses by 55% and 70% at 2 mM and 20 mM BSO doses, respectively, compared to untreated mice. Co-treatment with 2 mM BSO and 20 mM NAC depleted GSH to a similar extent as 2 mM BSO, consistent with the function of BSO to inhibit the g-GCS enzyme indispensable for GSH synthesis. Like GSH, cysteine levels dropped following BSO treatment.
丁硫氨酸-亚砜亚胺 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2025-02-08 | HY-106376A | 丁硫氨酸-亚砜亚胺 | 83730-53-4 | 50mg | 600 |
2025-02-08 | HY-106376A | 丁硫氨酸-亚砜亚胺 | 83730-53-4 | 10mM * 1mLin Water | 660 |