aselacin C

Aselacin C is a cyclic pentapeptolide antagonist of endothelin receptor type A (ET_A) and ET_B originally isolated from Acremonium.¹ It inhibits the binding of endothelin-1 to isolated bovine atrial membranes and porcine cerebral membranes, which endogenously express high levels of ET_A and ET_B, respectively, with IC₅₀ values of 60 and 80 μg/ml, respectively.

1. Jackson, M., Burres, N.S., Karwowski, J.P., et al. Aselacins, novel compounds that inhibit binding of endothelin to its receptor. I. The producing organism, fermentation and biological activity J. Antibiot. 47(5),523-527(1994).