Description
Aselacin C is a cyclic pentapeptolide antagonist of endothelin receptor type A (ET
A) and ET
B originally isolated from
Acremonium.
1 It inhibits the binding of endothelin-1 to isolated bovine atrial membranes and porcine cerebral membranes, which endogenously express high levels of ET
A and ET
B, respectively, with IC
50 values of 60 and 80 μg/ml, respectively.
References
1. Jackson, M., Burres, N.S., Karwowski, J.P., et al.
Aselacins, novel compounds that inhibit binding of endothelin to its receptor. I. The producing organism, fermentation and biological activity J. Antibiot. 47(5),523-527(1994).
