Prothracarcin is an antibiotic with antitumor activity that exerts its tumor cell toxicity by covalently binding to the C-2 amino group of guanine residues in the minor groove of DNA. Prothracarcin also shows antibacterial activity against Gram-positive bacteria and some Gram-negative bacteria such as Escherichia coli[1].
References
[1] Fotso, et al. Limazepines A F, Pyrrolo [1, 4] benzodiazepine Antibiotics from an Indonesian Micrococcus sp. Journal of natural products 72.4 (2009): 690-695. DOI:10.1021/np800827w
