conantokin R

Potent, non-competitive NMDA receptor antagonist (IC50= 93 nM) that has been suggested to have NR2 subunit selectivity. Inhibits inward currents evoked by NMDA in central nervous system neurons (IC50= 350 nM) and exhibits broad anticonvulsant and antiparkinsonian activityin vivoat doses devoid of behavioral toxicity.